OK . I'm not a researcher nor a chemist, pharmacist,doctor or any of that stuff. I am curious ( and we know what that did to the cat), but here's my thoughts:|
In reading about all the drugs related to PD, YOPD, and Plus diseases, other then DBS, all the treatments or drugs are taken orally. These drugs can cause serious stomach issues, ya'll know, with proteins etc. So why hasn't anyone come up with an injectable version of, let's say, Requip? OR as in some cancer treatments they put a thingy under the skin that allows meds to go right to the bloodstream.
They could put a thingy (please excuse the technical terms), under the skin near the brain where the dopamine is depleted, inject it with Ldopa, and Presto! Drug goes to brain sooner and lasts longer.
Am I being to simple? I know there are more adverse effects then the stomach issues, but, you would think with all the research done, why they haven't looked more into that OR am i missing something?
Of course, i do have a conspiracy theory on drug companies and research. I won't go into that as not to offend anyone, but i have to wonder.
Now i'm not saying they do a labotomy and go backwards in the realm of medicine. Insulin is one good example of how a drug can work, through the veins and gets to where it needs to be in a better time frame. I myself hate needles, but had to give injections both to mom and gram, as a caregiver, for they both were diabetic. However, if it works better and lasts longer, why not?
On to another issue .....
I also was reading more on Lewy Body Disease and found this thing called anterograde amnesia. While reading up on this, it seems that they found that positive and negative responses go a long way in regards to compulsive behaviors.
The most common are compulsions for gambling, sex, shopping, food, eating, or even hobbies. THey say people exhibit “punding,” or repetitive, purposeless behaviors such as sorting objects. A lot of the time the compulsion involves a behavior the person used to enjoy as a small hobby.
We all know about punishment and reward. They have come to find PWP,not taking dopamine based drugs, tend to learn better by punishment then by reward.However on dopamine drugs they do better with the rewards for good behaviors, then punishment for bad. They did this research on YOPDrs not taking any meds at that point, yet daignosed with the disease. In older studies, an older age group was used, but they were well into the disease, along with having cognitive issues and mood disorders. So basically, they feel the need to not just stress making the physical symptoms easier to maintain life, but to really take a look at the cognitive issues and the behaviors before and after dopamine drugs are used.
Soooooo ... if we as caregivers can learn HOW to react when these behaviors come apparent, then we can get the postive response from the LO instead of the negative responses some get.
Maybe nothing new to some of you, but to me it shed a lot of light on the subject.
This study was done in Hungary, and there's a lot more to it then i posted but I didn't want to put everyone to sleep..........