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That PD is caused by a dopamine deficiency has been the main theory behind the disease for over 50 years. Here is an article disputing that, and arguing that it's the balance of the neurotransmitters that is critical, and that simply replacing one will not fix the problem (we have 50 years of history to prove that latter point, as PWP do not get better by taking sinemet). Granted, the authors have a financial interest, but I think this is really interesting. Here's the link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282597/ Problem is, I don't think a single neuro we've ever seen would have the foggiest idea of how to go about testing my husband's neurotransmitter levels, nor how to balance them out. Additionally, the article indicates that the levels can fluctuate from day to day, so one day the test might indicate serotonin is low, the next, could be epinephrine, etc. Has anyone tried balancing their loved one's neurotransmitters, and if so, where did you go and how did it work out? |
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lurking, that is what Your Neurologist tries to do with the medicines prescribed for Parkinson's Disease. They are trying to balance the neurotransmiters in the brain. Some like L/Dopa for the dopamine and others act to block or stimulate nerve endings recieving signals from chemicals in the brain. When trying to balance the levels in the brain you go to your Neurologist. If you personally want you can ask for a referal for brain scans which when dyes are injected into the blood will show up in these scans reflecting amounts and places in the brain with too much, too little or normal amounts of the chemicals scanned for. For those fifty years mentioned Neurologists have been doing the best they can with the technology (drugs and operations) available to them to keep balance in the levels of our brains as those dopamine levels fall from the death of the cells producing it. |
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I would suspect that the fluctuations occur even more frequently than day to day. Perhaps it is minute to minute. The testing done only noted a fluctuation from one day to the next because that is the frequency with which their tests were performed. I believe trying to manually balance not only l-dopa, but the epinephrine or serotonin, for example, would be like trying to find a needle in a haystack. |