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Topic adverse reaction to serequel Go to previous topic Go to next topic Go to higher level

By Rempt2 On 2013.02.09 11:57
Hi, my husband was diagnosed last October. He probably had PD for years. In December he developed problems with constipation and pain. So much he started saying he couldn't live with it. This lead to an emergency room visit and placement in a geratric psyche unit (he is 67). Prior to admittance (Jan 6) he was able to walk 1/2 mile, stand etc. His PD symptoms weren't that bad. Onthe unit they gave hm serequel and one week later he had a fall on the unit. Over the next week he further declined eventually needing a wheelchair and a catheter as he couldn't use the bathroom (he couldn't stand without support). After many complaints to the dr and nursing staff they had him seen by a neurologist who said he was on the wrong med and they changed it to clozinal. He was discharged to a rehab unit and continues to show signs of decline. The neurologist said PD doesn't advance this fast. He will be coming home in a few weeks but I've been told he can't stay alone anymore. He sees his own neurologist next week via a chair car. Hopefully he has some solution that can make things better. Has anyone had a similar experience with this medicine or PD advancing so rapidly. One month ago he was a different person. Thank you.

By mylove On 2013.02.09 13:07
See the response on Housemouse's post just below yours re: infections and sudden decline. Yours does sound more like it's involved somehow in the medication. Can anyone else speak to adverse effects with Seroquel?

Praying this is a temporary, though scary, setback for you. Please stay strong and have faith. Let us know what happens.

By Rempt2 On 2013.02.13 11:25
update on husband. He has gone backwards in his rehab. He is having problems feeding himself. Staff has helped him but OT is trying to get him to do it for himself. He can still walk with a walker so that's good. As long as he can walk he can come home and we'll deal with other issues with his own drs. He is seeing his own neurologist (via chair car) on Friday. Hope he has a miracle in his bag. Thanks

By Rempt2 On 2013.02.15 13:17
Update as of today 2/15/12: Husband saw neurologist and he increased parkinson's meds to 5 1/2 a day. Said it may reverse symptoms. He didn't know why his decline was so sudden but on rare occasions the Serequel does have this reaction. It is one of 2 meds that won't worsen most cases of PD. Probably why no one else had this experience and replied, no one else had an issue with this med. Anyway onward and upward. I hope he can come home to his own drs. Rehabs/Skilled nursing facilities don't always establish the best habits for patients. He is having difficulting feeding himself (creates a mess). It's easier for them to feed him. OT says he can do it but it takes patience.

By parkinit On 2013.02.15 20:55
Thanks for the updates. We do care!

By karolinakitty On 2013.02.21 20:45
Rempt...i don't get on here as much anymore but saw your post....

Here is a link to the seroquel and how docs ignore the warnings in giving it and other antipsychotics to people with PD

http://www.webmd.com/parkinsons-disease/news/20110711/antipsychotics-used-for-parkinsons-despite-warnings

It's hard to say this but in our experiences ith the neuro world....we TELL the doc what we want....we don't let them just give us meds...everyone is different and reacts different....so everyone doesn't fit in the PD box and they really need to realize it....

One of our friends and board members is a Movement Specialist with PD....she has changed her views on the box theory and speaks out to the medical community on it now....hopefully she can reach her colleagues

By Rempt2 On 2013.03.03 20:42
thanks for the link. One line really is ironic "Seroquel (quetiapine), has failed to show positive results in three studies.". I guess the prescribing dr didn't read the 3 studies. He is on clozaril now. His parkinsons symptoms are still increasing but slower, no reversal yet. He's getting another Mri and seeing his neurologist again when out of rehab. Maybe another parkinson med will help.

By blue2 On 2013.03.04 12:05
Rempt2,
Hospital and rehab drs put my husband on serequel for hallucinations, but it had no helpful effect. His neurologist confirmed it is largely ineffective although it is one of two meds prescribed for PD hallucinations. My husband is now on clozaril/clozapine and it has helped reduce intensity and frequency of hallucinations. It sure is a pain in the neck to get though. Requires weekly blood tests for 6 months, then bi-weekly for another 6 months. Tightly controlled, not all pharmacies will carry it. Side effect can be sleepiness, but we're not seeing an obvious increase. Oh - blood test is for possible dramatic drop in white blood cells which can happen in "elderly" patients.

By lurkingforacure On 2013.03.04 18:26
This was a disaster for my mom (not PD), made her very upset, anxious, and not calming at all. Just our experience.

By Rempt2 On 2013.03.15 18:58
Husbandhas been home one week and continues to lose ability to walk on his own. This afternoon he was sitting in his wheel chair watching Dr. Phil. He leaned severely to the side even with bolster. he couldn't use walker to walk to bed so had to stumble into bed with help of gait belt. His muscles just locked. The leaning is on the right side. He can't keep himself centered.

VNA suggested their hospice program that would provide more services. I'm waiting until his neurologist reviews an mri he is getting Wed. For him PD is not a slow progressive disease. He has the fast track type it appears. His only pd meds are sinemet right now.

By LOHENGR1N On 2013.03.16 00:13
Remrt2, Some of the problems you mention could be side-effects of His Clozapine. A quick look online and some effects mentioned; muscle weakness, stiff (rigid) muscles, twitching or uncontrollable movements, tremors, drowsiness, increased sweating. I'd suggest calling His Neurologist and discussing the problems with them. That being said I would also make some notes about how these are affecting Him and you.

The Doctor prescribed the medication as they think the benefits outweigh the side-effects. You are there 24/7 and live with the side-effects too. So discuss them with the Doctor let the Doctor know them and affects. By doing that the Doctor is more informed and might knowing the problems adjust the medicine or make changes in them for better control and quality of living.

As these are known side-effects the Doctor will know or if they look them up just figure okay they're to be expected. But they have no idea the impact upon your Husband, You do. As an example side-effect of muscle stiffness or weakness. You have to make them aware of how you have to try to hold him up and control his movement hanging onto a gait belt struggling to keep yourself and your husband upright till He reaches the bed! Keep notes and bring them to be discussed with the Doctor. Doctors will nod when side-effects are brought up (they expect them) but they need to know the impact of them and that Patients and their Caregivers don't know about them or what to expect. When We aren't informed of effects we are at a loss and scared of what's happening of what's going wrong now!

You mention a bolster? They won't stop leaning to the side and have been discouraged by many they may cause discomfort in patients who lean anyway.

I hope this helps some. Please keep us posted as we care about you and your husband. Take care, best of luck and hang in there.

By Rempt2 On 2013.03.21 21:47
Almost 2 weeks from rehab and we are getting into a routine. He is transitioning better between wheelchair and bed. PT came in first week and he was alseep (because of med change). she almost wrote him off. Next visit he was awake and she did several exercises with him. Afterwards I noticed immediate improvement. He was able to stand for a short time and his feeding himself was much improved. During day he is pretty good but nights are another thing. His meds wear off and he shakes extremely badly, legs moving, hands trembling. He also cries out and seems to hallucinate. Going over this with his drs. He's not the same person at night and neither of us sleep. I just held his hand in a strong grip last night and he relaxed for awhile. He had MRI today and will be seeing neurologist in a week. Accomplishment this week was going to church. It was an effort getting out the front door into car but pastor welcomed him back and he said he was glad to be back. Condo assoc may actually approve automatic door opener for front door.

By LOHENGR1N On 2013.03.22 18:49
Rempt, Thanks for the update! Hope things continue to get better as time goes on it can take only a couple of days to put us where it takes months to get back close to where we were. Again thanks for the update and We're all pulling for your and yours. Sincerely Al.

By Rempt2 On 2013.03.23 17:07
Thanks for your reply. It means a lot. Husband lost a lot of cognative ability since January. He was an accountant and kept track of bank account etc. He wanted to go on computer today and update. We had statements from bank. He had a hard time manipulating keyboard with me next to him. In rehab they did test and he had trouble adding simple columns even though you'd expect an accountant to do this. He also forgot how to use computer, follow links, do searches. This is something me and aides are working on. He has lost skills but still has his personality (thank goodness). He had stomach bug today with usual issues. He's so fragile (weight now 126 and 5 feet 11). Have hired one great person to help out. She's very grateful to have found work after one year. If you live in new england there are some good people at rewardingwork.org. You have to screen of course and do background checks. Hubby still wants to travel to Washington DC. Maybe we'll make it.

By LOHENGR1N On 2013.03.23 18:57
Yes rewarding work.org is a very good place to find caring workers. I've had a couple from there over the years. I'm glad you found someone to help you out! I'm in Western Massachusetts. Off the subject a bit now all we need is spring to get here! Take care, best of luck and hang in there!


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