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Topic Clinical Studies and Trials Go to previous topic Go to next topic Go to higher level

By jcoff012 On 2013.02.28 09:30
Just received this. May/may not be of value to many, but worth reposting...

It has been awhile since the Stanford APDA Parkinson's Information & Referral Center published a list of all of the PD, MSA, PSP, or CBD research studies currently recruiting at non-profit institutions in Northern California. (If you don't know what MSA, PSP, or CBD are, just skip those.) But my colleague Steven Russell has spent the last few weeks compiling the list below as we hope to encourage you to participate in one of these studies!

When we say "research study," we are referring to:

* clinical trials where there is an intervention tested -- a drug, therapy, or
experimental treatment

* observational studies where participants are observed over time

There are quite a few research studies going on at three movement disorder
centers in Northern California -- Stanford University, The Parkinson's Institute, and University of California San Francisco. We've listed those that are actively recruiting below.

Some of these centers have studies for which ONLY their patients may participate. These studies are NOT part of the list below.

You can always search for actively-recruiting clinical trials by visiting clinicaltrials.gov. There are many search options including a basic search

(Parkinsonís and Stanford), advanced search (Recruitment: Open Studies
recruiting; Conditions: Parkinsonís; State 1: United States/California; Location

Terms: Stanford) or a combination of search terms including name of trial, name
of sponsor, trials with results, etc.

Another resource, requiring pre-registration, is Fox Trial Finder -

foxtrialfinder.michaeljfox.org.

Fox Trial Finder works like a dating website, where those in search of a trial and researchers in search of participants can find each other, communicate securely, and pre-screen for matches of interest.

Some of the research facilities do not have adequate staffing to enter all of their trials and all of the details of the participants being sought, so the information will not be as complete as on clinicaltrials.gov.

For good background on types of clinical trials, trial phases, why it is so important that more people volunteer for trails, etc, see this Michael J. Fox Foundation webpage:

foxtrialfinder.michaeljfox.org/info-for-volunteers/clinical-trials-101/

Here's what's going on at a movement disorder center near you....

STANFORD UNIVERSITY

1-SU: Development of multimodal imaging biomarkers for cognitive dysfunction in
Parkinsonís disease

Purpose: Our goal is to better understand brain networks and biological markers
associated with memory changes in Parkinsonís disease, and to find ways of
detecting these changes before memory problems develop.

Principal Investigator: Kathleen Poston, MD, MS. This study is funded by the
Michael J. Fox Foundation for Parkinsonís Research.

Contact: Sophie YorkWilliams, sophiey@stanford.edu, 650-774-8688

2-SU: Early Differential Diagnosis of Parkinsonism with Metabolic Imaging and
Pattern Analysis

Purpose: Our goal for this research is to develop imaging markers that will more accurately diagnose parkinsonian disorders, such as Parkinsonís disease,

Multiple System Atrophy, Progressive Supranuclear Palsy, and Corticobasal
Degeneration.

Principal Investigator: Kathleen Poston, MD, MS. This study is funded by the
NIH.

Contact: Hadar Keren-Gille, hadarkq@stanford.edu, 650-724-4131

3-SU: Parkinsonís Genetic Research Study (PaGeR)

Purpose: The PaGeR study is searching for genes that increase the risk of developing PD and related disorders. PaGeR is focusing on families in which two or more people have been diagnosed with PD. Past research suggests that such "multiplex" families might hold the key to the discovery of new PD genes.

Stanford Site Investigator: Rosalind Chuang, MD. This study is funded by the
NIH.
Webpage: thepagerstudy.org

Contact: Erica Martinez, ekovak@uw.edu, 855-646-4221. Initial contact is handled by the coordinating center at the University of Washington and the VA Puget Sound Health Care System in Seattle.

4-SU: Sensory Feedback to Improve Freezing of Gait (FOG) in Parkinsonís
disease: Is an ecologically valid sound more efficacious than other auditory feedback to improve FOG in PD?

Purpose: Testing sensory feedback (quantitative digitography, quantitative
wrist flexion/extension, computerized dynamic posturography and stepping in
place both on and off medications, and for those with DBS before and after surgery) to study improvements in freezing of gait, postural control, reaction time and rhythmicity, determined via UPDRS.

Principal Investigator: Helen Bronte-Stewart, MD, MSE
Contact: Lauren A. Shreve, lashreve@stanford.edu, 650-855-4656

5-SU: Is Freezing of Gait (FOG) also manifest in movements of the upper
extremities?

Purpose: Testing sensory feedback (quantitative digitography, quantitative
wrist flexion/extension, computerized dynamic posturography and stepping in
place both on and off medications, and for those with DBS before and after
surgery) to study improvements in freezing of gait, postural control, reaction time and rhythmicity, determined via UPDRS with a particular focus on the upper extremities.

Principal Investigator: Helen Bronte-Stewart, MD, MSE

Contact: Lauren A. Shreve, lashreve@stanford.edu, 650-855-4656

6-SU: Fine limb and axial motor control study of people with MSA and PSP.

Purpose: Testing sensory feedback (quantitative digitography, quantitative
wrist flexion/extension, computerized dynamic posturography and stepping in
place both on and off medications) to study improvements in fine limb and axial motor control.

Principal Investigator: Helen Bronte-Stewart, MD, MSE

Contact: Lauren A. Shreve, lashreve@stanford.edu, 650-855-4656
THE PARKINSON'S INSTITUTE AND CLINICAL CENTER

You can always find a list of "actively recruiting" clinical trials and studies
here:

For Patients - thepi.org/current-clinical-trials

For Family Members - thepi.org/family-friends-caregivers

1-TPI: Disease-modifying Potential of Transdermal NICotine in Early Parkinson's
Disease (NIC-PD)
Purpose: To demonstrate that transdermal nicotine treatment retards disease

progression as measured by change in total Unified Parkinson's Disease Rating Scale (UPDRS)(part I, II, III) score between baseline and after 52 weeks of study treatment plus two more months wash out (60 weeks).

Webpage: clinicaltrials.gov/ct2/show/NCT01560754

Contact: The PI's clinical trials office voicemail 408-542-5608 or email
trials@thepi.org

2-TPI: Effect of Rotigotine on Motor Symptoms in Patients with Advanced
Parkinsonís Disease with Motor Fluctuations and Gastroparesis (ROADMAP)

Purpose: The primary purpose is to demonstrate superiority of Rotigotine over
Placebo on motor symptoms when used in subjects with Gastroparesis. Hypothesis:
Rotigotine will improve gastric emptying times.

Webpage: clinicaltrials.gov/ct2/show/NCT01536015

Contact: The PI's clinical trials office voicemail 408-542-5608 or email
trials@thepi.org

3-TPI: A Study Assessing Change in Sense of Smell After Rasagiline Use in
Parkinson's Patients (PD-SOAR)

Purpose: To see if there is change in sense of smell after starting Rasagiline
(brand name: Azilect).

Webpage: clinicaltrials.gov/show/NCT01007630

Contact: The PI's clinical trials office voicemail 408-542-5608 or email
trials@thepi.org

4-TPI: The Parkinsonís Progression Markers Initiative (PPMI)

Purpose: To identify clinical, imaging and biologic markers of PD progression
for use in clinical trials of disease-modifying therapies.

Webpage: clinicaltrials.gov/ct2/show/NCT01141023 and

michaeljfox.org/page.html?parkinsons-progression-markers-initiative

Contact: The PI's clinical trials office voicemail 408-542-5608 or email
trials@thepi.org

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

You can find general information on PD research at UCSF here:
pdcenter.neurology.ucsf.edu/research

1-UCSF: Domain-specific tasks of executive function in Parkinsonís disease

Purpose: To develop more sensitive measures of cognitive functioning that may
be useful for clinical trials.

Webpage: pdcenter.neurology.ucsf.edu/research/get-involved-open-trials/cognitive-study-executive-function-pd

Contact: Erica Johnson, ejohnson@memory.ucsf.edu, 415-476-1883

2-UCSF: New Approaches to Parkinson's Disease Research - A research program to
improve early detection and clinical care (in conjunction with the SF VA)

Purpose: To develop imaging markers for diagnosing Parkinson's disease and
measuring disease progression.

Webpage: pdcenter.neurology.ucsf.edu/research/get-involved-open-trials/parkinsons-disease-signature-imaging

Contact: Erica Johnson, ejohnson@memory.ucsf.edu, 415-476-1883

3-UCSF: Spatial cognition in neurodegenerative disease

Purpose: To develop more sensitive measures of cognitive functioning that may
be useful for clinical trials.

Webpage: pdcenter.neurology.ucsf.edu/research/get-involved-open-trials/spatial-cognition


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